Potentiation of bioreductive agents

Details Potentiation of bioreductive agents Potentiation of bioreductive agents

A - Human Necessities

61

K

A61K 33/00 (2006.01) A61K 31/41 (2006.01) A61K 31/415 (2006.01) A61K 31/675 (2006.01)

Patent

CA 2122509

ABSTRACT OF THE DISCLOSURE A human or animal subject having a solid tumour is treated by administering to the subject therapeutically effective amounts of a nitric oxide (NO) synthase inhibitor and a compound which is an imidazole or 1,2,4-triazole derivative of formula (A) Image wherein X is selected from the group consisting of Image Image and wherein R is hydrogen or a C1-C6 alkyl group; each of R'1 to R'5 is independently selected from the group consisting of hydrogen, C1-C6 alkyl, hydroxy(C1-C6 alkyl), phenyl, (C1-C6 alkyl)phenyl and phenyl(C1-C6 alkyl); m is 0 or 1; n is 1 or 2; and Z' represents a leaving group which has the potential for expulsion via an intramolecular cyclisation reaction and which is not negatively-charged; or a physiologically acceptable acid addition salt thereof.

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