Heteroaryl derivatives as cftr modulators

Details Heteroaryl derivatives as cftr modulators Heteroaryl derivatives as cftr modulators

C - Chemistry, Metallurgy

07

D

C07D 213/75 (2006.01) A61K 31/435 (2006.01) A61K 31/4965 (2006.01) A61K 31/505 (2006.01) A61P 3/00 (2006.01) A61P 25/00 (2006.01) C07D 239/42 (2006.01) C07D 241/20 (2006.01)

Patent

CA 2716109

The present invention relates to modulators of ATP-B inding Cassette ('ABC') transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ('CFTR'), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

La présente invention concerne, d'une part des modulateurs de transporteurs de cassette de liaison à l'ATP ou "ABC" (ATP-Binding Cassette) ou certains de leurs fragments, et notamment le régulateur de conductance transmembranaire de fibrose cystique ou "CFTR" (Cystic Fibrosis Transmembrane Conductance Regulator), les compositions qui en découlent, et d'autre part des procédés associés. La présente invention concerne également des procédés d'utilisation de tels modulateurs pour le traitement de maladies imputables à une médiation du transporteur d'ABC.

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