Use of antiresorptive compounds to prevent radiation-induced...

A - Human Necessities – 61 – K

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A61K 31/663 (2006.01) A61K 31/675 (2006.01) A61P 19/00 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01)

Patent

CA 2620932

A method of preventing or treating radiation-associated loss of bone mass, bone density or bone strength in a subject is provided, comprising administering to the subject an amount of an anti-resorptive or osteoclast inhibiting compound sufficient to prevent or mitigate loss of bone mass, density or strength. A method of preventing or treating radiation-associated increase in the number or activity of osteoclasts in a subject is also provided, comprising administering to the subject an amount of an anti- resorptive compound sufficient to reduce osteoclast numbers or reduce osteoclast activity.

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