Th2 cell depletion; compositions; methods

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 5/0783 (2010.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2309761

Binding compositions which selectively bind to a marker specifically found on Th2 cells and various methods of use of the binding compositions are provided. In particular, the method makes use of fact that the CCR8 chemokine receptor is selectively expressed on the Th2 cell subset. Preferably, the binding composition is a monoclonal antibody specific for CCR8.

Cette invention, qui a trait à des compositions de liaison se liant de manière sélective à un marqueur présent de manière spécifique sur des cellules Th2, concerne également diverses méthodes d'utilisation de ces compositions. La méthode fait, notamment, usage du fait que le récepteur de chémokine CCR8 est exprimé de manière sélective dans le sous-ensemble de cellule Th2. La composition de liaison est, de préférence, un anticorps monoclonal spécifique de CCR8.

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