A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01)
Patent
CA 2390685
The present invention concerns methods and compositions for inhibiting neoplastic cell growth. In particular, the present invention concerns antitumor compositions and methods for the treatment of tumors. The invention further concerns screen-ing methods for identifying growth inhibitory, e.g., antitumor compounds. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypep-tide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
La présente invention se rapporte à des procédés et à des compositions permettant d'inhiber la croissance cellulaire néoplasique. Elle se rapporte notamment à des compositions antitumorales et à des méthodes de traitement des tumeurs. L'invention se rapporte également à des méthodes de criblage permettant d'identifier des composés inhibiteurs de croissance, notamment des composés antitumoraux. La présente invention se rapporte à des polypeptides et à des molécules d'acides nucléiques codant lesdits polypeptides. Elle se rapporte en outre à des vecteurs et à des cellules hôtes comportant ces séquences d'acides nucléiques, à des molécules polypeptidiques chimères comportant les polypeptides de la présente invention accolés à des séquences polypeptidiques hétérologues, à des anticorps qui se lient aux polypeptides de la présente invention et à des procédés de production des polypeptides ci-dessus décrits.
Ashkenazi Avi J.
Goddard Audrey
Gurney Austin L.
Napier Mary A.
Watanabe Colin K.
Dennison Associates
Genentech Inc.
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