Non-gelatin soft capsule system

Details Non-gelatin soft capsule system Non-gelatin soft capsule system

A - Human Necessities

61

K

A61K 9/48 (2006.01) A61K 9/66 (2006.01)

Patent

CA 2585721

A non-gelatin encapsulation system for liquid filled soft capsules, by nature of the carrier, the cationic-ionic balance of the carrier and the active ingredients, or the concentration of the active ingredients and excipients, are difficult or impossible to commercially encapsulate in gelatin capsules. In particular, the system is adapted for the encapsulation of highly basic, or alkaline, fills. The system provides for a predominantly starch and gelling carrageenan based shell, which displays high resistance to both concentrated fills and to alkaline fills, in particular, to those fills which contain the salt or salts of weak acids and strong bases.

L'invention concerne un système d'encapsulation non gélatineux de capsules molles remplies de liquide, qui, en raison de la nature du support, de l'équilibre cationique-ionique du support et des principes actifs, ou de la concentration des principes actifs et des excipients, sont difficiles, voire impossibles à encapsuler commercialement dans des capsules gélatineuses. Plus particulièrement, ce système est adapté pour l'encapsulation de charges fortement basiques ou alcalines. D'autre part, ce système comprend une enveloppe qui contient essentiellement de l'amidon et du carraghénane gélifiant. La composition de l'enveloppe confère ainsi une résistance élevée à la fois aux charges concentrées et aux charges alcalines, en particulier, aux charges qui renferment un ou plusieurs sels d'acides faibles et de bases fortes.

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