Crystalline form of an antifungal azole

Details Crystalline form of an antifungal azole Crystalline form of an antifungal azole

C - Chemistry, Metallurgy

07

D

C07D 249/08 (2006.01) A61K 31/41 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2194567

A crystalline form of the antifungal agent (+)-2-(2,4-difluorophenyl)-1-[3- [(E)-4-(2,2,3,3-tetrafluoropropoxy)-styryl]-1H-1,2,4-triazol-1-yl]-3- (1H- 1,2,4-triazol-1-yl)propan-2-ol (code D0870) is described. Furthermore processes for the preparation thereof, to pharmaceutical compositions comprising said crystalline form and to the use thereof in therapy are described.

L'invention concerne une forme cristalline de l'agent antifongique (+)-2-(2,4-difluorophényle)-1-(3-((E)-4-(2,2,3,3-tétrafluoropropoxy)-styryle)-1H-1,2,4-triazole-1-yle)-3-(1H-1,2,4-triazole-1-yle)propane-2-ol (code D0870). Elle concerne également des procédés servant à la préparer, des compositions pharmaceutiques comprenant ladite forme cristalline, ainsi que son utilisation thérapeutique.

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