Process for preparing ergoline derivatives

Details Process for preparing ergoline derivatives Process for preparing ergoline derivatives

C - Chemistry, Metallurgy

07

D

C07D 457/00 (2006.01) A61K 31/48 (2006.01) C07D 457/02 (2006.01) C07D 457/12 (2006.01)

Patent

CA 2049053

2049053 9111447 PCTABS00006 Ergoline derivatives of formula (I), wherein R represents hydrogen or C1-C4 alkyl; R1 represents hydrogen, chlorine, bromine or methyl; either R2 and R3 both represent hydrogen or together represent a chemical bond; R4 represents a C1-C4 hydrocarbon group; each of R5, R6, R8 and R9 independently represents hydrogen or C1-C4 alkyl; R7 represents hydrogen, C1-C4 alkyl, phenyl or C3-C7 cycloalkyl and n is 0, 1 or 2; are prepared by reaction between compounds of formulae (II) and (III), and subsequent cyclization of the resultant compounds. The compounds of formula (I) are known useful anxiolytic, antipsychotic and anti-parkinson agents.

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