Use of an enterobacterium protein ompa for specific...

A - Human Necessities – 61 – K

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A61K 39/385 (2006.01) A61K 39/39 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2350183

The invention concerns the use of an enterobacterium protein OmpA, preferably Klebsiella pneumoniae P40 protein, for specific targeting of a biologically active substance associated therewith towards antigen-presenting cells, in particular human dendritic cells. The invention also concerns the use of the OmpA protein for preparing a pharmaceutical composition for preventing and/or treating diseases, in particular cancers related to a tumour-associated antigen, autoimmune diseases or infectious diseases.

L'invention concerne l'utilisation d'une protéine OmpA d'entérobactérie, de préférence la protéine P40 klebsiella pneumoniae, pour le ciblage spécifique d'une substance biologiquement active qui lui est associée vers les cellules présentatrices d'antigènes, notamment les cellules dendritiques humaines. L'invention a également pour objet l'utilisation de la protéine OmpA pour la préparation d'une composition pharmaceutique destinée à la prévention et/ou le traitement de maladies, notamment les cancers associés à un antigène tumoral, les maladies auto-immunes ou les maladies infectieuses.

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