C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/06 (2006.01)
Patent
CA 2531208
The invention relates to a peptide immune booster, comprising: a polypeptide (i) with an amino acid sequence having a length of 30 amino acids contained in the head domain of the fibre protein of the capsid of an adenovirus, said amino acid sequence comprising the sequence of amino acids forming a double .szlig. sheet called EF, contained in said head domain, or a peptide analogue (ii) of said polypeptide (i), the amino acid sequence of which has, by comparison with the sequence of polypeptide (i), at least one substitution or at least one deletion of an amino acid, said analogue peptide conserving the double .szlig. sheet called EF .
L~invention concerne un composé peptidique adjuvant de l~immunité consistant en : - un polypeptide (i) comprenant une séquence d~acides aminés de 30 acides aminés de longueur contenue dans le domaine « tête » de la protéine « fibre » de la capside d~un adénovirus, ladite séquence d~acides aminés comprenant l~enchaînement d~acides aminés formant la structure en double feuillet .beta. désignée « EF » contenue dans ledit domaine « tête » ; ou - un peptide (ii) analogue dudit polypeptide (i) dont la séquence en acides aminés comporte, par rapport à la séquence dudit polypeptide (i), au moins une substitution ou au moins une délétion d~un acide aminé, ledit peptide analogue conservant ladite structure en double feuillet .beta. désignée « EF ».
Blondel Armelle
Boulanger Pierre
Boulanger Saw See
Briand Jean-Paul
Frenkel Valerie
Centre National de La Recherche Scientifique (cnrs)
Gowling Lafleur Henderson Llp
Inserm (institut de La Sante Et de La Recherche Medicale)
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