C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 333/50 (2006.01) A61P 29/00 (2006.01) C07D 333/74 (2006.01) C07D 333/80 (2006.01)
Patent
CA 2492922
The present invention provides substituted thiophene carboxamide compounds having structural Formula I and isomers, tautomers, polymorphs, carriers, prodrugs, and pharmaceutically acceptable salts thereof, compositions comprising such, and methods for treating diseases associated with kinase activity. More specifically, the present invention provides methods of treatment of a variety of diseases associated with IKK2 including the treatment of inflammation, other inflammation-associated disorders, such as, as an analgesic in the treatment of pain and headaches, arthritis, including but not limited to rheumatoid arthritis, asthma, gastrointestinal conditions such as inflammatory bowel disease, vascular diseases, viral infections such as AIDS, and cancer.
La présente invention concerne des composés de thiophène carboxamide substitués de formule structurelle (I) et des isomères, tautomères, polymorphes, supports, promédicaments et sels de ceux-ci, acceptables d'un point de vue pharmaceutique, des compositions comprenant ces composés, ainsi que des procédés pour traiter des maladies associées à une activité de kinase. Cette invention concerne plus particulièrement des procédés pour traiter une variété de maladies associées à IKK2, notamment pour traiter une inflammation, d'autres troubles associés à une inflammation, par exemple en tant qu'analgésique pour traiter la douleur et les maux de tête, l'arthrite, notamment la polyarthrite rhumatoïde, l'asthme, des pathologies gastro-intestinales comme une affection abdominale inflammatoire, des maladies vasculaires, des infections virales comme le SIDA, et le cancer.
Clare Michael
Hagen Timothy J.
Houdek Stephen C.
Weier Richard M.
Xu Xiangdong
Pharmacia Corporation
Smart & Biggar
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