C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/14 (2006.01) A61K 31/517 (2006.01) C07D 239/91 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2368097
The invention concerns amide derivatives of Formula (Ia) wherein X is - NHCO- or -CONH-; m is 0-3; R1 is a group such as hydroxy, halogeno, trifluoromethyl, cyano, mercapto, nitro, amino, carboxy and carbamoyl; n is 0-2; R2 is a group such as hydroxy, halogeno, trifluoromethyl, cyano, mercapto, nitro, amino and carboxy; R3 is hydrogen, halogeno, (1-6C)alkyl or (1-6C)alkoxy; q is 0-4; and Q is a group such as aryl, aryloxy, aryl-(1-6C)alkoxy, arylamino and N-(1- 6C)alkyl-arylamino; or pharmaceutically-acceptable salts or in-vivo-cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.
L'invention concerne des dérivés amides représentés par le formule (Ia). Dans cette formule X est -NHCO- ou -CONH-; m est 0-3; R<1> est un groupe hydroxy, halogéno, trifluorométhyle, cyano, mercapto, nitro, amino ou carboxy et carbamyle; n est 0-2; R<2> est un groupe hydroxy, halogéno trifluorométhyle, cyano, mercapto, nitro ou amino et carboxy; R<3> est hydrogène, halogène, (1-6C)alkyle ou (1-6C)alcoxy; q est 0-4; Q est un groupe aryle, aryloxy, aryle-(1-6C)alcoxy, arylamino and <u>N</u>-(1-6C)alkyle-arylamino. Cette formule peut être composée de sels pharmaceutiquement acceptables ou d'esters clivables <u>in-vivo</u> de ces groupes. L'invention concerne aussi des processus de préparation de ces dérivés, des compositions pharmaceutiques les contenant et leur utilisation dans le traitement de maladies ou d'états pathologiques induits par les cytokines.
Astrazeneca Ab
Smart & Biggar
LandOfFree
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