Anticonvulsant derivatives useful in treating cluster headaches

Details Anticonvulsant derivatives useful in treating cluster headaches Anticonvulsant derivatives useful in treating cluster headaches

A - Human Necessities

61

K

A61K 31/255 (2006.01) A61K 31/35 (2006.01) A61K 31/7048 (2006.01) A61P 25/00 (2006.01) A61P 25/06 (2006.01)

Patent

CA 2359541

The use of anticonvulsant derivatives of formula (I) treating cluster headaches is disclosed. Wherein X is CH2 or oxygen; R1 is hydrogen of C1-C4 alkyl; and R2, R3, R4 and R5 are independently hydrogen or C1-C3 alkyl and, when X is CH2, R4 and R5 may be alkene groups joined to form a benzene ring and, when X is oxygen, R2 and R3 and/or R4 and R5 together may be a methylenedioxy group of the following formula (II): wherein R6 and R7 are the same or different and are hydrogen, C1-c~3 alkyl or R6 and R7 together with the carbon to which they are attached are joined to form a cyclopentyl or cyclohexyl ring.

La présente invention concerne des dérivés anti-convulsifs permettant de traiter les céphalées vasculaires de Horton.

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