Receptor-ligand pairing for anti-inflammatory response

Details Receptor-ligand pairing for anti-inflammatory response Receptor-ligand pairing for anti-inflammatory response

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 31/00 (2006.01) A61K 31/683 (2006.01) A61K 31/685 (2006.01) A61K 47/48 (2006.01) A61P 19/00 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2368656

A composition of matter capable of producing an anti-inflammatory response in vivo in a mammal comprises bodies having a three-dimensional core structure of conformation and size corresponding to mammalian apoptotic cells and/or bodies and expressing or expressible on the surface thereof a plurality of the same or different ligands which will react, optionally in the presence of adapter molecules, with at least one specific receptor wherein the binding of said ligand(s) with said receptors produces an anti-inflammatory response in vivo in said mammal, with the proviso that when said ligands are of the same type, said ligands are not PS.

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