Inhibition of stearoyl-coa desaturase 1 (scd1) increases...

Details Inhibition of stearoyl-coa desaturase 1 (scd1) increases... Inhibition of stearoyl-coa desaturase 1 (scd1) increases...

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/202 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61K 31/439 (2006.01) A61K 31/4439 (2006.01) C12N 9/02 (2006.01)

Patent

CA 2493584

It is disclosed here that insulin sensitivity in a human or non-human animal can be increased by reducing stearoyl-CoA desaturase-1 (SCD 1) activity in the animal. This provides a new tool for treating and preventing type 2 diabetes. Also disclosed are methods for identifying agents that can increase insulin sensitivity in a human or non-human animal through determining the agents' effects on SCD1 activity.

L'invention concerne la possibilité d'augmenter la sensibilité à l'insuline chez un être humain ou un animal par le biais de la diminution de l'activité du gène stéaroyl-CoA désaturase-1 (SCD 1). Cette invention a trait à un nouvel outil permettant de traiter et de prévenir les diabètes de type 2, ainsi qu'à des méthodes d'identification d'agents qui peuvent accroître la sensibilité à l'insuline chez un être humain ou un animal par détermination des effets des agents sur l'activité SCD1.

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