Novel compounds

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/18 (2006.01) A61K 31/70 (2006.01) A61K 38/18 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/71 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2216625

GDNF alpha 3 receptor polypeptides and polynucleotides and methods for producingsuch polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing GDNF alpha 3 receptor polypeptides and polynucleotides in the design of protocols for the treatment of neurodegenerative diseases (such as Parkinson's Disease, amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA), Huntington's Disease, Alzheimer's Disease, diabetic neuropathy), muscular diseases (including the muscular dystrophies) and nerve and muscle trauma, among others and diagnostic assays for such conditions.

La présente invente porte sur des polypeptides et des polynucléotides des récepteurs alpha 3 du GNDF (glial derived neurotrophic factor) ainsi que sur des méthodes de production de ces polypeptides par des techniques de recombinaison génétique. On y décrit aussi des méthodes d'utilisation des polypeptides et polynucléotides des récepteurs alpha 3 du GNDF dans la conception de protocoles de traitement des maladies neurodégénératives (comme la maladie de Parkinson, la sclérose latérale amyotrophique (SLA), l'amyotrophie spinale progressive, la maladie de Huntington, la maladie d'Alzheimer et la neuropathie diabétique), des maladies musculaires (dystrophies musculaires progressives), des atteintes nerveuses et musculaires, entre autres, ainsi que dans la mise au point d'épreuves diagnostiques pour ces affections.

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