C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/14 (2006.01) A61K 31/53 (2006.01) A61K 45/06 (2006.01) A61K 45/08 (2006.01) A61P 3/10 (2006.01) C07D 251/16 (2006.01) C07D 251/22 (2006.01) C07D 401/12 (2006.01) C07D 403/04 (2006.01) C07D 405/12 (2006.01)
Patent
CA 2379791
This invention is directed to sorbitol dehydrogenase inhibitory compounds of formula I Image wherein R1, R2 and R3 are as defined in the specification. This invention is also directed to pharmaceutical compositions containing these compounds which inhibit sorbitol dehydrogenase and to methods of treating or preventing diabetic complications, particularly diabetic neuropathy, diabetic nephropathy, diabetic microangiopathy, diabetic macroangiopathy, diabetic cardiomyopathy and foot ulcers, by administering such compounds to a mammal suffering from diabetes and therefore at risk for developing such complications. This invention is also directed to pharmaceutical compositions comprising a combination of a compound of formula I of the present invention with a second pharmaceutical agent, including an aldose reductase inhibitor, a sodium hydrogen ion exchange (NHE-1) inhibitor, a glycogen phosphorylase inhibitor (GPI), a selective serotonin reuptake inhibitor, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, an angiotensin converting enzyme inhibitor, a thiazolidinedione antidiabetic agent, an angiotensin II receptor antagonist, a .gamma.-aminobutyric acid (GABA) agonist, a phosphodiesterase type 5 inhibitor, an adenosine agonist, and a CETP inhibitor and to methods of using these combination compositions.
Pfizer Products Inc.
Smart & Biggar
LandOfFree
Novel triazine compounds useful as sorbitol dehydrogenase... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Novel triazine compounds useful as sorbitol dehydrogenase..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel triazine compounds useful as sorbitol dehydrogenase... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2033433