Compounds for the treatment of an acute injury to the...

Details Compounds for the treatment of an acute injury to the... Compounds for the treatment of an acute injury to the...

A - Human Necessities

61

K

A61K 31/64 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2571718

The invention relates to K<SB>ATP </SB>channel closers (KCCs) which can be used for the therapeutic and/or prophylactic treatment of an acute injury to the central nervous system (CNS) of a mammal, including a human, given that the administration thereof potentiates the neuroprotective microglial effect, particularly in the case of glibenclamide. As a result, the aforementioned K<SB>ATP </SB>channel closers can be used in the treatment of the acute phase of CNS diseases, such as ictus, convulsions, axonal lesions, traumatic injuries, neurodegeneration, spinal cord lesions and autoimmune and infectious diseases of the CNS. In addition, isotopically-modified KCCs can also be used for the preparation of diagnostic agents for the detection and monitoring of an acute injury to the CNS.

Les inhibiteurs du canal de K<SB>ATP</SB> (KCC) sont utiles dans le traitement prophylactique et/ou thérapeutique d'une lésion aiguë du système nerveux chez un mammifère, entre autres un être humain, parce que son administration, notamment dans le cas de la glybenclamide, offre l'effet de la microglie neuroprotectrice. Par conséquent, ils peuvent être utiles dans le traitement de la phase aiguë des maladies du système nerveux telles que l'ictus, les convulsions, la lésion axonale, les troubles traumatiques, la neurodégénérescence, la lésion de la médule spinale et les maladies auto-immunes et infectieuses du système nerveux central. Les KCC modifiés isotopiquement, sont également utiles dans la préparation d'agents de diagnostic pour la détection et le suivi d'une lésion aiguë du système nerveux central.

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