Pyridine derivatives and processes for their synthesis

C - Chemistry – Metallurgy – 07 – D

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C07D 491/20 (2006.01) C07D 213/61 (2006.01) C07D 213/64 (2006.01) C07D 491/04 (2006.01) C07D 491/052 (2006.01) C07F 7/10 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2037590

64680-594 Abstract The present invention relates to processes and inter- mediates for the preparation of spiro-heteroazolones of the formula: Image (wherein R3 is lower alkyl). The latter compounds are useful as aldose reductase inhibitors. The intermediates include those of the formulae Image , Image , Image and Image (wherein R3 is lower alkyl, Q is Cl, Br, F or OSO2R4 [where R4 is alkyl, CF3 or optionally substituted phenyl] and Z is negative charge, H or hydroxy-protecting group).

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