4-aryl-1,2,3,4-tetrahydropyrrolo(3,4-b) indoles

Details 4-aryl-1,2,3,4-tetrahydropyrrolo(3,4-b) indoles 4-aryl-1,2,3,4-tetrahydropyrrolo(3,4-b) indoles

C - Chemistry, Metallurgy

07

D

260/298.5

C07D 487/04 (2006.01) A61K 31/40 (2006.01)

Patent

CA 1055949

ABSTRACT OF THE DISCLOSURE 2-Substituted-4-aryl-1,2,3,4-tetrahydropyrrolo[3,- 4-b]-indoles of the Formula I Image and the pharmaceutically acceptable acid addition salts thereof, wherein X is selected from fluoro, chloro, bromo, methyl and hydrogen; Z is selected from fluoro, methoxy, chloro and hydrogen; and R is selected from alkyl having 1 to 6 carbon atoms, benzyl and substituted alkylene of the formula Image wherein A is alkylene having 1 to 5 carbon atoms, M is selected from -CH=CH-, -CH2-, Image , Image and Image wherein R1 is selected from hydrogen and alkanoyl having 2 to 5 carbon atoms and Y is selected from fluoro, methyl, chloro and hydrogen, their use as tranquilizing agents and their pre- paration from 4-aryl-1,2,3,4-tetrahydropyrrolo[3,4-b]indoles.

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