C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/04 (2006.01) A61K 31/19 (2006.01) A61K 31/192 (2006.01) A61K 31/385 (2006.01)
Patent
CA 2244848
The present invention provides a method of inhibiting influenza and flaviviral replication based on a mechanism of action in which HA-mediated fusion or E protein mediated fusion is inhibited by a fusion inhibiting agent which binds, complexes or otherwise becomes associated with HA or E protein during the translation of the target protein and/or its vesicular transport.
La présente invention concerne un procédé d'inhibition de la réplication de la grippe et d'une infection à flavivirus à partir d'un mécanisme d'action dans lequel la fusion induite par HA ou la fusion induite par la protéine E est inhibée par un agent inhibiteur de fusion qui fixe, complexe ou s'associe sinon à HA ou à la protéine E au cours de la translation de la protéine cible et/ou de son transport vésiculaire.
Colacino Joseph Matthew
Hatch Steven Duane
Hornback William Joseph
Muesing Mark Ayer
Munroe John Edwin
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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