A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/575 (2006.01)
Patent
CA 2253593
Methods for the prevention and treatment of colorectal cancer are provided. Specifically, the method relates to the administration of an effective adenoma or microadenoma preventing amount of 6-fluoroursodeoxycholic acid (6-FUDCA) or a pharmaceutically acceptable salt or pharmaceutically acceptable conjugate thereof to a mammal in need of such treatment. The methods find general use in the prevention of the formation of secondary bile acids, the reduction of deoxycholic acid, and the protection against cytotoxic effects of other bioacids and carcinogens.
L'invention concerne des méthodes de traitement et de prévention du cancer colorectal. Spécifiquement, elle concerne l'administration d'une quantité, efficace pour prévenir la survenue d'adénomes ou de microadénomes, d'acide 6-fluoro-ursodésoxycholique (6-FUDCA), ou d'un sel ou d'un conjugué pharmaceutiquement acceptable dudit acide, à un mammifère ayant besoin d'un tel traitement. De manière générale, elle est utile pour prévenir la formation d'acides biliaires secondaires, diminuer le taux d'acide désoxycholique et protéger contre les effets cytotoxiques d'autres bioacides ou carcinogènes.
Capuano Leonard Robert
Gibson Joyce Corey
Fetherstonhaugh & Co.
Novartis Ag
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