C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 241/04 (2006.01) C07C 311/32 (2006.01) C07D 211/60 (2006.01) C07D 211/62 (2006.01)
Patent
CA 2525886
The invention relates to N-sulphonylated amino acid derivatives wherein an aryl radical is bound to an amino acid via the sulphonyl groups in the N- terminal and a radical is bound in the C-terminal via the carbonyl group. Said radical contains at least one imino group and at least one other basic group representing an optionally modified amino-, amidino- or guanidino group. The invention also relates to a method for the production of said compounds and to the use thereof, especially as inhibitors of matriptase.
Dérivés d'acides aminés N-sulfonylés, dans lesquels un reste aryle est lié à l'acide aminé via le groupe sulfonyle en position N-terminale et un reste est lié en position C-terminale via le groupe carbonyle, ledit reste possédant au moins un groupe imino et au moins un autre groupe basique représentant un groupe amino, aminidino ou guanidino éventuellement modifié. La présente invention concerne également un procédé de fabrication de ces composés et leur utilisation, en particulier comme inhibiteurs de la matriptase.
Schweinitz Andrea
Steinmetzer Torsten
Stuerzebecher Anne
Stuerzebecher Joerg
Uhland Kerstin
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Curacyte Chemistry Gmbh
The Medicines Company (leipzig) Gmbh
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