C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/16 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) A61P 37/00 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C12P 21/08 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2478012
The present invention provides humanized, chimeric and human anti-CD74 antibodies, CD74 antibody fusion proteins, immunoconjugates, vaccines and bispecific that bind to CD74, the major histocompatibility complex (MHC) class- II invariant chain, Ii, which is useful for the treatment and diagnosis of B- cell disorders, such as B-cell malignancies, other malignancies in which the cells are reactive with CD74, and autoimmune diseases, and methods of treatment and diagnosis.
La présente invention concerne des anticorps anti-CD74 humanisés, chimériques et humains, des protéines de fusion d'anticorps CD74, des immunoconjugués, des vaccins et des anticorps bispécifiques se liant à CD74, la chaîne invariante du complexe majeur d'histocompatibilité (MHC) de classe II, Ii, qui est utile pour le traitement et le diagnostic de troubles associés aux cellules B, tels que les tumeurs malignes des cellules B, les autres tumeurs malignes dans lesquelles les cellules réagissent avec CD74, ainsi que les maladies auto-immunes. L'invention concerne également des méthodes de traitement et de diagnostic.
Goldenberg David M.
Hansen Hans
Leung Shui-On
Qu Zhengxing
Immunomedics Inc.
Smart & Biggar
LandOfFree
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