H - Electricity – 01 – J
Patent
H - Electricity
01
J
H01J 49/42 (2006.01)
Patent
CA 2628924
A method of mass spectrometry is disclosed wherein an Electron Capture Dissociation, Electron Transfer Dissociation or Surface Induced Dissociation fragmentation device is repeatedly switched between a high fragmentation or reaction mode and a low fragmentation or reaction mode. Parent ions from a first sample are passed through the device and parent ion mass spectra and fragmentation ion mass spectra are obtained. Parent ions from a second sample are then passed through the device and a second set of parent ion mass spectra and fragmentation ion mass spectra are obtained. The mass spectra are then compared and if either certain parent ions or certain fragmentation ions in the two samples are expressed differently then further analysis is performed to seek to identify the ions which are expressed differently in the two different samples.
L'invention concerne un procédé de spectrométrie de masse dans lequel un dispositif fragmentation par dissociation par capture d'électrons, dissociation par transfert d'électrons ou dissociation induite par une surface passe de manière répétée d'un mode fragmentation ou réaction élevée à un mode fragmentation ou réaction faible. Des ions parents provenant d'un premier échantillon traversent le dispositif, et on obtient un spectre de masse d'ions parents et un spectre de masse d'ions issus de la fragmentation. Des ions parents provenant d'un second échantillon traversent ensuite le dispositif et on obtient un second ensemble de spectre de masse d'ions parents et de spectre de masse d'ions issus de la fragmentation. On compare ensuite les spectres de masse et, lorsque dans les deux exemples, certains ions parents ou certains ions issus de la fragmentation sont exprimés différemment, on effectue une analyse afin de les identifier.
Bateman Robert Harold
Micromass Uk Limited
Ridout & Maybee Llp
LandOfFree
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