Method of introducing a peptide into a cytosol

Details Method of introducing a peptide into a cytosol Method of introducing a peptide into a cytosol

A - Human Necessities

61

K

A61K 39/385 (2006.01) A61K 47/48 (2006.01) C07K 14/34 (2006.01) C12N 15/62 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2086342

2086342 9200099 PCTABS00010 A method of introducing a peptide into the cytosol by linking the peptide to a bacterial or plant toxin, or a mutant thereof. A method of preparing a vaccine by linking a peptide to a bacterial or plant toxin, or a mutant thereof to translocate the peptide into the cytosol for subsequent presentation at the cell surface by Class I MHC antigens to elicit a Class I restricted immune response and to expand the relevant population of CD8+ T-lymphocytes. Vaccines produced by said method and the use thereof against viruses, intracellular bacteria and parasites, and against molecules associated with malignancies.

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