C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 43/13 (2006.01) A61K 31/075 (2006.01) A61K 31/10 (2006.01) A61K 31/12 (2006.01) A61K 31/13 (2006.01) A61K 31/66 (2006.01) A61P 9/00 (2006.01) C07C 45/45 (2006.01) C07C 49/17 (2006.01) C07C 49/172 (2006.01) C07C 59/347 (2006.01) C07C 59/353 (2006.01) C07C 69/675 (2006.01) C07C 69/757 (2006.01) C07C 215/12 (2006.01) C07C 235/08 (2006.01) C07C 235/10 (2006.01) C07C 235/16 (2006.01) C07C 237/22 (2006.01) C07C 271/16 (2006.01) C07C 317/18 (2006.01) C07C 323/12 (2006.01) C07D 213/40 (2006.01) C07D 309/12 (20
Patent
CA 2480415
The invention relates to novel Acyl coenzyme-A mimics, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising a ketone compound. The Acyl coenzyme-A mimics, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, bacterial infection and impotence. In certain embodiments, the Acyl coenzyme-A mimics, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
L'invention concerne de nouveaux mimiques d'acyl-coenzyme A, des compositions contenant des composés cétone et des méthodes utilisées pour traiter et prévenir les maladies cardio-vasculaires, les dyslipidémies, les dysprotéinémies et les troubles du métabolisme du glucose. Ladite invention consiste à administrer une composition contenant un composé cétone. Les mimiques d'acyl-coenzyme A, les compositions, et les méthodes de l'invention sont également utiles pour traiter et prévenir la maladie d'Alzheimer, le syndrome X, les troubles liés au récepteur activé par le proliférateur de péroxisome, la septicémie, les troubles thrombotiques, l'obésité, la pancréatite, l'hypertension, la néphropathie, le cancer, l'inflammation, les infections bactériennes et l'impuissance. Dans certains modes de réalisation, les mimiques d'acyl-coenzyme A, les compositions, et les méthodes de l'invention sont utiles en polythérapie avec d'autres agents thérapeutiques, tels que les agents hypocholestérolémiants et hypoglycémiants.
Dasseux Jean-Louis
Oniciu Carmen Daniela
Esperion Therapeutics Inc.
Osler Hoskin & Harcourt Llp
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