Tripartite fusion proteins of glutathione s-transferase

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/62 (2006.01) C12N 9/10 (2006.01) C12N 15/11 (2006.01) C12N 15/54 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2132321

2132321 9319091 PCTABS00025 A tripartite fusion protein comprises a first amino acid sequence corresponding to a glutathione-S-transferase enzyme at its COOH terminus with a second amino acid sequence corresponding to a binding entity, particularly an immunological binding entity, followed by a third amino acide sequence corresponding to a different polypeptide fused with said binding entity. The protein may include a cleavable link between the first and second amino acid sequences and/or the second and third amino acid sequences. Recombinant DNA molecules and expression vectors coding for these fusion proteins are also disclosed.

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