Peptides that mimic gp120 hiv epitope

Details Peptides that mimic gp120 hiv epitope Peptides that mimic gp120 hiv epitope

C - Chemistry, Metallurgy

12

N

C12N 15/49 (2006.01) A61K 39/21 (2006.01) A61K 39/385 (2006.01) A61K 39/42 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/155 (2006.01) C07K 14/16 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2140151

The invention provides a molecule comprising a peptide having the amino acid sequence lysine-proline- cysteine-valine-lysine-leucine-threonine-proline-leucine- cysteine-valine (Seq.Id.No.1), wherein each cysteine resi- due is disulphide bridged to a further cysteine residue or is derivatised to simulate part of a disulphide bond, or functionally equivalent variants of such a peptide which mimic the immunogenic behaviour of an epitope of gp120 of HIV env. The sequence is highly conserved, being total- ly conserved in all listed isolates of HIV-1 and HIV-2, and undergoes only minor changes in isolates of SIV. With each cysteine residue contributing to a respective disulphide bridge (actual or simulated by suitable deriva- tisation), the molecule accurately mimics behaviour of the corresponding sequence of gp120 and elicits an immune response. The molecule can thus be used as the basis of a potential vaccine against AIDS and AIDS related condi- tions, and may find use in the treatment of AIDS and re- lated conditions.

Affiliated with

Also associated with

Rating

Peptides that mimic gp120 hiv epitope does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Peptides that mimic gp120 hiv epitope, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptides that mimic gp120 hiv epitope will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2035645