Uses for corticotropin releasing factor atagonists

Details Uses for corticotropin releasing factor atagonists Uses for corticotropin releasing factor atagonists

A - Human Necessities

61

K

A61K 31/505 (2006.01) A61K 31/435 (2006.01) A61K 31/437 (2006.01) A61K 31/44 (2006.01) A61K 31/506 (2006.01) A61K 31/519 (2006.01) A61K 31/52 (2006.01)

Patent

CA 2189830

Disclosed is a pharmaceutical composition for treating, preventing or inhibiting cardiovascular or heart related diseases, comprising (a) a compound of the formula Image or Image I II or a pharmaceutically acceptable salt thereof, wherein A is N or CR7 (in which R7 is H, alkyl, halo or the like), B is -NR1R2, -CR1 R2R11 or the like (in which R1 is H or alkyl, R2 is alkyl, aryl, arylalkyl, cycloalkyl or the like and R11 is H, OH or the like), D is N, -CR10 (in which R10 is H, alkyl, halo or the like ), C=O, -C=NH, etc.), E is -CR4 (in which R4 is H, alkyl, halo etc.), N, -NR6 or -CR4R6 (in which R4 is H, alkyl, halo, etc. and R6 is H or alkyl), Y is N or CH, Z is O, S, NH, ect., R3 is H, alkyl, halo, etc., R4 is H, alkyl, halo, etc. and R5 is a cyclic group, and (b) a pharmaceutically acceptable diluent or carrier.

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