C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/48 (2006.01) A61K 31/401 (2006.01) A61P 31/14 (2006.01) C07D 211/96 (2006.01) C07D 277/06 (2006.01) C07D 295/22 (2006.01) C07D 403/04 (2006.01)
Patent
CA 2640229
This invention is directed to compounds of formula (I): wherein R1, R2, X, and n are as defined herein, including all crystalline forms and pharmaceutically acceptable salts thereof, with the provisos that when X is CH2, n is 1, and R1 is -COOH, then R2 cannot be formula (A) wherein A is CH3-, CH3CH2- or a haloalkyl of 1 to 2 carbon atoms, and B is a halogen; and when X is CH2, n is 2, and R1 is -COOH, then R2 cannot be formula (A) or formula (B). The invention is also directed to compositions containing compounds of the invention and methods of using the compounds to treat or prevent hepatitis C virus infections.
L'invention concerne des composés de formule (I), dans laquelle R1, R2, X et n sont tels que définis dans le mémorandum descriptif, y compris toutes le formes cristallines et sels pharmaceutiquement acceptables desdits composés, à condition que, quand X est CH2, n est 1 et R1 est -COOH, alors R2 ne peut pas représenter la formule (A) dans laquelle A est CH3-, CH3CH2- ou un haloalkyle de 1 à 2 atomes de carbone, et B un halogène; et quand X est CH2, n est 2 et R1 est -COOH, alors R2 ne peut pas représenter la formule (A) ou la formule (B). L'invention concerne en outre des compositions contenant les composés de l'invention, et des méthodes d'utilisation des composés pour traiter ou prévenir des infections par le virus de l'hépatite C.
Torys Llp
Wyeth
LandOfFree
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