Purine derivatives as a2a agonists

Details Purine derivatives as a2a agonists Purine derivatives as a2a agonists

C - Chemistry, Metallurgy

07

D

C07D 473/16 (2006.01) A61K 31/52 (2006.01) A61P 11/00 (2006.01) C07H 19/167 (2006.01)

Patent

CA 2656012

Compounds of formula (I):or stereoisomers or pharmaceutically acceptable salts thereof, wherein W, R1,R 2 and R3 have the meanings as indicated in the specification, are useful for treating conditions mediated by activation of the adenosine A2A receptor, especially inflammatory or obstructive airways diseases. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

La présente invention concerne des composés de formule (I) ou des stéréoisomères ou encore des sels de ceux-ci acceptables sur le plan pharmaceutique, W, R1, R2 et R3 étant tels que définis dans le mémoire descriptif, lesquels composés sont utilisables pour le traitement de troubles à médiation par l'activation du récepteur A2A de l'adénosine, en particulier des maladies inflammatoires ou du syndrome respiratoire obstructif. Des compositions pharmaceutiques contenant ces composés et un procédé de préparation de ces composés sont également décrits.

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