Thiol-sensitive positive inotropes

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/135 (2006.01) A61K 31/13 (2006.01) A61P 9/04 (2006.01)

Patent

CA 2613477

The present invention relates to methods for treating diastolic dysfunction or a disease, disorder or condition associated with diastolic dysfunction, methods for treating heart failure, methods for modulating SR Ca2+ release and/or uptake, methods for enhancing myocyte relaxation, preload or E2P hydrolysis, and methods for treating ventricular hypertrophy.

La présente invention a trait à des procédés pour le traitement du dysfonctionnement diastolique ou une maladie, un trouble ou une condition associé(e) au dysfonctionnement diastolique, à des procédés pour le traitement de l'insuffisance cardiaque, à des procédés pour la modulation de la libération et/ou de l'absorption de SR Ca2+, à des procédés pour l'activation de la relaxation du myocyte, la précharge ou l'hydrolyse d'EP2, et à des procédés pour le traitement de l'hypertrophie ventriculaire.

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