The use of proteinase inhibitors for prevention or reduction...

Details The use of proteinase inhibitors for prevention or reduction... The use of proteinase inhibitors for prevention or reduction...

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 31/70 (2006.01) A61K 38/03 (2006.01) A61K 38/08 (2006.01) A61K 38/55 (2006.01) A61K 48/00 (2006.01) C07K 1/04 (2006.01) C07K 14/81 (2006.01) C07K 16/40 (2006.01)

Patent

CA 2261567

Bone metabolic disease is treated by inhibition of the production or action of membrane-type matrix metalloproteinase (MT-MMP) or the matrix metalloproteinase 12 (MMP-12) involved in the resorptive activity of osteoclasts. Inhibitors for MT-MMP and MMP-12 and membrane-associated metalloproteinase activity include peptides and analogues of peptides generated using a PEGA bead library, antisense nucleic acid agents and antibodies. The proteinases MT1-MMP and MMP-12 are found to be expressed in osteoclasts and may be selectively inhibited.

L'invention concerne un traitement de maladies métaboliques des os, par inhibition de la production ou de l'action d'une métalloprotéinase matricielle de type membranaire (MT-MMP) ou de la métalloprotéinase matricielle 12 (MMP-12), impliquées dans l'activité de résorption des ostéoclastes. Les inhibiteurs de MT-MMP et de MMP-12 et de l'activité des métalloprotéinases associée aux membranes comprennent des peptides et des analogues de peptides produits à partir d'une banque de billes PEGA, des agents acides nucléiques antisens et des anticorps. On a découvert que les protéinases MT1-MMP et MMP-12 sont exprimées par des ostéoclastes et peuvent être inhibées de façon sélective.

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