Polypeptides, antibody variable domains and antagonists

Details Polypeptides, antibody variable domains and antagonists Polypeptides, antibody variable domains and antagonists

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2688434

The invention relates to anti-TNFR1 polypeptides and antibody single variable domains (dAbs) that are resistant to degradation by a protease, as well as antagonists comprising these. The polypeptides, dAbs and antagonists are useful for as therapeutics and/or prophylactics that are likely to encounter proteases when administered to a patient, for example for pulmonary administration, oral administration, delivery to the lung and delivery to the GI tract of a patient, as well as for treating inflammatory disease, such as arthritis or COPD.

L'invention porte sur des polypeptides anti-TNFR1 et sur des domaines variables uniques d'anticorps (dAbs) qui sont résistants à la dégradation par une protéase, ainsi que sur des antagonistes les comprenant. Les polypeptides, les dAb et les antagonistes sont utiles en tant qu'agent thérapeutiques et/ou prophylactiques qui sont susceptibles de rencontrer des protéases lorsqu'ils sont administrés à un patient, par exemple, pour une administration pulmonaire, une administration orale, une administration au poumon et une administration au tractus gastro-intestinal d'un patient, ainsi que pour un traitement d'une maladie inflammatoire, telle que l'arthrite ou la broncho-pneumopathique chronique obstructive (COPD).

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