The transcriptional promoter of the obesity gene

Details The transcriptional promoter of the obesity gene The transcriptional promoter of the obesity gene

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) C07K 14/575 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2236076

The invention relates to the Ob gene transcriptional promoter. The subject promoters generally comprise a C/EBP binding site and a novel untranslated Ob gene exon. Ob gene promoters are used in diagnosis and pharmaceutical development. In particular, transfected adipocytes comprising Ob gene promoters operably linked to a reporter are used in high-throughput pharmaceutical screens.

La présente invention concerne le promoteur transcriptionnel du gène Ob. Les promoteurs concernés comportent généralement un site de liaison du C/EBP et un exon d'un gène Ob non traduit de l'invention. Ces promoteurs du gène Ob sont utilisés en diagnostics et dans la recherche pharmaceutique. En particulier, on utilise dans des criblages pharmaceutiques à haut débit des adipocytes transfectés comprenant des promoteurs du gène Ob fonctionnellement liés à un gène reporteur.

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