Polymer therapy for the treatment of chronic microvascular...

A - Human Necessities – 61 – K

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A61K 31/765 (2006.01) A61K 49/00 (2006.01) A61L 31/06 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2695151

Methods are provided for the treatment of chronic microvascular diseases characterized by inflammation, such as age-related macular degeneration, by administering a polyoxyethylene/polyoxypropylene copolymer. Although a single dose can be effective, multiple treatments can be administered to achieve an optimal and sustained effect. Preferably, a single administration followed by repeated weekly administration of the pharmaceutical composition, but not continuous infusion, achieves a desired effect. Methods of diagnosis and characterization of chronic microvascular diseases using the copolymer are also provided.

La présente invention concerne des procédés utilisés dans le traitement de maladies microvasculaires chroniques caractérisées par l'inflammation, telle que la dégénérescence maculaire liée à l'âge. Ledit traitement consiste en l'administration d'un copolymère polyoxyéthylène/polyoxypropylène. Bien qu'une dose unique puisse être efficace, il est possible d'administrer des traitements multiples afin d'obtenir un effet optimal et continu. De préférence, une administration unique suivie d'une administration hebdomadaire répétée de ladite composition pharmaceutique, mais pas d'une perfusion continue, permet d'obtenir un effet désiré. La présente invention concerne également des procédés de diagnostic et de caractérisation de maladies microvasculaires chroniques au moyen dudit copolymère.

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