Vitamin d analogues

Details Vitamin d analogues Vitamin d analogues

C - Chemistry, Metallurgy

07

C

C07C 401/00 (2006.01) A61K 31/59 (2006.01) A61K 31/66 (2006.01) A61K 31/70 (2006.01) C07F 9/117 (2006.01) C07H 15/207 (2006.01)

Patent

CA 2065849

A novel compound of Formula (I) (See Formula I) is provided herein. In such compound, R1 and R2 may be the same or different and stand for hydrogen, C1-C5- alkyl, C3-C7 cycloalkyl, or taken together with the carbon atom (starred in Formula I), bearing the groups X, R1 and R2, form a C3-C8 carbocyclic ring; X stands for hydrogen or hydroxy, R3 and R4, which may be the same or different stand for hydrogen, C1-C5 alkyl or halogen, n is 0, 1 or 2 and m is 0, 1 or 2. Derivatives of the compound of Formula I in which at least one hydroxy group has been transformed into -O-acyl, or -O-glycosyl or phosphate ester groups, the ester groups being hydrolysable in vivo, are also provided. Such compounds, which find use both in human and veterinary practice, show an immunomodulating effect, as well as strong activity in inducing differentiation and inhibiting undesirable proliferation of certain cells, including cancer cells and skin cells.

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