C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/52 (2006.01) A61K 38/16 (2006.01) A61K 38/19 (2006.01) A61K 47/42 (2006.01) A61P 31/18 (2006.01) C07K 14/435 (2006.01) C07K 14/765 (2006.01) C07K 19/00 (2006.01)
Patent
CA 2446739
The present invention relates to novel chemokine polypeptides and encoding nucleic acids. More specifically, therapeutic compositions and methods are provided using isolated nucleic acid molecules encoding a human chemokine beta- 1 (Ck$G(b)-1 or Ckb1) polypeptide (previously termed monocyte-colony inhibitory factor (M-CIF), MIP1-gamma, and Hemofiltrate CC chemokine-1 (HCC- 1)), and Ckb1 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same. Also provided are methods of treating, preventing, ameliorating diseases using such compounds.
L'invention concerne de nouveaux polypeptides de chimiokine et de nouveaux acides nucléiques les codant. En particulier, l'invention concerne des compositions et des méthodes thérapeutiques faisant appel à des molécules d'acide nucléique isolées codant un polypeptide beta-1 de chimiokine humaine (Ck.beta.-1 ou Ckb1) (anciennement connu sous le nom de facteur inhibiteur de colonies de monocytes (M-CIF), MIP1-.gamma., et à de la chimiokine-1 CC d'hémofiltrat (HCC-1)), et à des polypeptides Ckb1 eux-mêmes, ainsi qu'à des vecteurs, des cellules hôtes et des méthodes de recombinaison permettant de les produire. L'invention concerne également des méthodes de traitement, de prévention et de soulagement de maladies faisant appel à ces composés.
Bell Adam
Ruben Steven M.
Human Genome Sciences Inc.
Mbm Intellectual Property Law Llp
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