C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/00 (2006.01) A01N 57/00 (2006.01) A61K 31/685 (2006.01)
Patent
CA 2532795
The invention provides sense antiviral compounds and methods of their use in inhibition of growth of viruses of the Flaviviridae, Picornoviridae, Caliciviridae, Togaviridae, Coronaviridae families and hepatitis E virus in the treatment of a viral infection. The sense antiviral compounds are substantially uncharged morpholino oligonucleotides having a sequence of (12- 40) subunits, including at least (12 )subunits having a targeting sequence that is complementary to a region associated with stem-loop secondary structure within the 3'-terminal end (40) bases of the negative-sense RNA strand of the virus.
L'invention concerne des composés antiviraux sens et des méthodes utilisées pour inhiber la croissance des virus des familles Flaviviridae, Picornoviridae, Caliciviridae, Togaviridae, Coronaviridae et du virus de l'hépatite E dans le traitement d'une infection virale. Les composés antiviraux sens sont sensiblement non chargés d'oligonucléotides dits morpholino comprenant une séquence de 12-40 sous-unités, notamment au moins 12 sous-unités comprenant une séquence de ciblage complémentaire d'une région associée à une structure secondaire tige-boucle dans les 40 bases d'extrémité de terminaison 3' du brin d'ARN de sens négatif du virus.
Avi Biopharma Inc.
Gowling Lafleur Henderson Llp
LandOfFree
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