Hmg coa reductase inhibitors for promoting angiogenesis

Details Hmg coa reductase inhibitors for promoting angiogenesis Hmg coa reductase inhibitors for promoting angiogenesis

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/22 (2006.01) A61K 31/366 (2006.01) A61K 31/40 (2006.01) A61K 31/404 (2006.01) A61K 31/4418 (2006.01) A61K 38/00 (2006.01) A61K 38/55 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2411396

This invention relates to methods and compositions for the treatment of conditions associated with vascular insufficiency, and to methods and compositions for screening assays to select agents that are useful for this purpose. In particular the invention relates to HMG CoA reductase inhibitors and their use in promoting angiogenesis in vivo and in activating Akt in vascular endothelial cells in vitro and in vivo.

L'invention concerne des procédés et des compositions pour le traitement d'états associés à une insuffisance vasculaire, ainsi que des méthodes et des compositions pour des dosages permettant la sélection d'agents utiles à cet effet. L'invention porte, notamment, sur des inhibiteurs de la HMG CoA réductase et sur leur utilisation dans la promotion de l'angiogenèse in vivo et dans l'activation d'Akt dans les cellules endothéliales vasculaires, in vitro et in vivo.

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