Specific salt forms of triphenylethylene derivatives as...

Details Specific salt forms of triphenylethylene derivatives as... Specific salt forms of triphenylethylene derivatives as...

C - Chemistry, Metallurgy

07

C

C07C 51/41 (2006.01) A61K 31/19 (2006.01) A61K 31/42 (2006.01) A61K 31/535 (2006.01) A61P 5/30 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) C07C 57/42 (2006.01)

Patent

CA 2403263

This invention pertains to novel salt forms of trophenylethylene compound, such as 3-[4(1,2-diphenyl-but-1-enyl)-phenyl]-acrylic acid, as selective estrogen receptor modulators. This invention also provides methods for the treatment and/or prevention of breast, uterine, ovarian, prostrate and colon cancer, osteoporosis, cardiovascular disease, and benign proliferative disorders, as well as pharmaceutical compositions of the compounds of the present invention.

L'invention concerne de nouvelles formes de sels de composé de trophényléthylène telles que l'acide 3-[4(1,2-diphényl-but-1-enyl)-phényl]-acrylique utilisées comme modulateurs sélectifs des récepteurs d'oestrogène. L'invention concerne aussi des procédés pour le traitement et/ou la prévention du cancer du sein, de l'utérus, des ovaires, de la prostate et du côlon ainsi que de l'ostéoporose, des maladies cardio-vasculaires et des troubles prolifératifs bénins ainsi que des compositionspharmaceutiques à base des composés de la présente invention.

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