Production of polyketides and other natural products

Details Production of polyketides and other natural products Production of polyketides and other natural products

C - Chemistry, Metallurgy

07

D

C07D 498/18 (2006.01) A61K 31/436 (2006.01) C12P 17/18 (2006.01)

Patent

CA 2621093

The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).

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