A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61N 7/02 (2006.01) C12N 15/85 (2006.01) C12N 15/861 (2006.01)
Patent
CA 2263706
The invention provides methods for using local heat to control gene expression. The heat shock protein (hsp) gene promoter is recombined with a selected therapeutic gene and expressed in selected cells. Local controlled heating is used to activate the hsp promoter, for example by using focused ultrasound controlled by MRI.
L'invention décrit des méthodes d'utilisation d'une source de chaleur locale pour réguler l'expression génique. On recombine le promoteur du gène protéique du stress (hsp) avec un gène thérapeutique sélectionné exprimé dans des cellules choisies. On utilise une source de chaleur locale régulée pour activer le promoteur hsp, en utilisant, par exemple, des ultrasons focalisés commandés par un imageur à résonance magnétique (IRM).
Fetherstonhaugh & Co.
The Government Of The United States Of America
LandOfFree
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