C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/06 (2006.01) A61F 6/00 (2006.01) A61K 31/70 (2006.01) A61L 31/00 (2006.01) C07H 21/00 (2006.01) C12N 9/99 (2006.01) C12N 15/11 (2006.01) C12Q 1/70 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2145664
Modified oligonucleotides having a conserved G4 sequence and a sufficient number of flanking nucleotides to signifi- cantly inhibit the activity of a virus such as HSV-1 or phospholipase A2 or to modulate the telomere length of a chromosome are provided. G4 quartet oligonucleotide structures are also provided. Methods of prophylaxis, diagnostics and therapeutics for viral-associated diseases and diseases associated with elevated levels of phospholipase A2 are also provided. Methods of modulating telomere length of a chromosome are also provided; modulation of telomere length is believed to play a role in the aging process of a cell and in control of malignant cell growth.
Anderson Kevin P.
Bennett C. Frank
Brown-Driver Vickie L.
Chiang Ming-Yi
Ecker David J.
Isis Pharmaceuticals Inc.
Isis Pharmaceuticals Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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