Novel internal ribosome entry site, vector containing same...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/85 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 35/76 (2006.01) A61K 48/00 (2006.01) C12N 7/01 (2006.01) C12N 15/867 (2006.01)

Patent

CA 2194155

A novel internal ribosome entry site and a novel region for the encapsidation of a retrotransposon, and murine VL30s in particular, are disclosed. A vector and a eukaryotic cell containing said site and region, and their therapeutical or prophylactic use, are also disclosed.

La présente invention a pour objet un nouveau site interne d'entrée des ribosomes et une nouvelle région d'encapsidation d'un rétrotransposon et notamment des VL30 murins. Elle concerne également un vecteur et une cellule eucaryote les contenant ainsi que leur usage thérapeutique ou prophylactique.

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