Process for the synthesis of hmg-coa reductase inhibitors

Details Process for the synthesis of hmg-coa reductase inhibitors Process for the synthesis of hmg-coa reductase inhibitors

C - Chemistry, Metallurgy

07

F

C07F 7/18 (2006.01)

Patent

CA 2624471

A novel synthesis of statins uses Wittig reaction of a heterocyclic core of statin with a lactonized side chain already possessing needed stereochemistry. Any separation of diastereoisomers is preformed early in the course of synthesis.

L'invention concerne une nouvelle synthèse de statines qui utilise la réaction de Wittig d'un noyau hétérocyclique de statine avec une chaîne latérale lactonisée possédant déjà la stéréochimie requise. Toute séparation de diastéréoisomères est réalisée au cours de la synthèse.

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