Methods and compositions for preventing oxidative...

Details Methods and compositions for preventing oxidative... Methods and compositions for preventing oxidative...

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61K 47/18 (2006.01) C07K 16/00 (2006.01)

Patent

CA 2492143

Methods and compositions for preventing oxidative damage to proteins, particularly antibodies, are provided. The compositions include a combination of metal chelators, such as DTPA, EGTA, and/or DEF, and can further include one or more free radical scavengers, particularly scavengers of oxygen radicals. Methods for enhancing protein stability using the compositions of the invention are also disclosed.

Procédés et compositions visant à prévenir les dégradations oxydatives produites sur les protéines, en particulier sur les anticorps. Les compositions comprennent une combinaison de chélateurs métalliques tels que DTPA, EGTA et/ou DEF, ainsi qu'un ou plusieurs piégeurs de radicaux libres, en particulier des piégeurs des radicaux d'oxygène. Des procédés visant à renforcer la stabilité des protéines à l'aide des compositions de l'invention sont également décrits.

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