Peptides and methods for the control of obesity

Details Peptides and methods for the control of obesity Peptides and methods for the control of obesity

A - Human Necessities

61

K

A61K 38/07 (2006.01) C07K 5/107 (2006.01) C07K 5/117 (2006.01)

Patent

CA 2524862

Disclosed is a peptide derivative having the formula: X1-Z-Q-arg-trp-NH2, wherein: X1 is an acyl group, Z is amino-2-naphthyl-carboxylic acid or histidine, Q is (D)phenylalanine or p-iodo-(D)phenylalanine, or a pharmacologically acceptable salt, complex or derivative thereof, the peptide derivative having melanocortin-4 receptor agonist activity.

L'invention concerne un dérivé peptidique de formule X?1¿-Z-Q-arg-trp-NH¿2,? dans laquelle X?1¿ est un groupe acyle, Z désigne un acide amino-2-naphthyle-carboxylique ou histidine, Q désigne (D)phénylalanine ou p-iodo-(D)phénylalanine, ou un sel, un complexe ou un dérivé pharmacologiquement acceptable de celles-ci, le dérivé peptidique présentant une activité agoniste par rapport au récepteur de la mélanocortine-4.

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