Detecting abnormal reactions in a red blood cell agglutination

Details Detecting abnormal reactions in a red blood cell agglutination Detecting abnormal reactions in a red blood cell agglutination

G - Physics

01

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G01N 33/49 (2006.01) G01N 15/04 (2006.01) G01N 33/555 (2006.01) G01N 33/80 (2006.01) G06K 9/00 (2006.01) G01N 30/38 (2006.01)

Patent

CA 2244346

Abnormal reactions in a red blood cell classification by agglutination, are checked following centrifugation of a sample in a column of a cassette, the column containing microparticles. This is done by imaging the column on a detector array that is used to correlate the images with predefined red cell classes based upon the distribution of the images across the column. However, prior to the correlation step, abnormal reactions are checked for by detecting whether any of the following is present: i) errors that cause imaged features of the column or any pellet produced therein to be out of range; ii) hemolysis of the sample; iii) insufficient or too many blood cells present; iv) mixed field agglutination; and v) presence of fibrin at the top of the microparticles.

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